How does the risk of developing hypoglycemia compare between preterm and term newborns shortly after resuscitation?

The risk of developing hypoglycemia is indeed higher in preterm newborns shortly after resuscitation. This increased risk can be attributed to several factors related to their developmental stage and physiological characteristics.

Preterm infants often have immature metabolic pathways and a lower capacity to manage glucose levels due to their limited stores of glycogen. Their liver, which plays a crucial role in gluconeogenesis (the production of glucose), is often underdeveloped, making it more challenging for them to maintain stable blood glucose levels after birth, especially following stressors like resuscitation.

Additionally, preterm newborns frequently have a higher incidence of complications such as infection, thermal instability, and poor feeding tolerance, all of which can contribute to increased metabolic demands and potential hypoglycemia. This contrasts with term newborns, who typically have more developed metabolic processes and are generally better equipped to stabilize their blood glucose levels shortly after birth.

Understanding this difference is essential for healthcare professionals managing preterm infants, as it emphasizes the need for close monitoring of blood glucose levels in this vulnerable population immediately after resuscitation.